{"id":21,"date":"2026-03-23T13:29:34","date_gmt":"2026-03-23T12:29:34","guid":{"rendered":"https:\/\/theengineeringreview.com\/zh-tw\/2026\/03\/23\/%e8%83%bd%e5%90%a6%e7%9b%b4%e6%8e%a5%e5%9c%a8%e9%ab%94%e5%85%a7%e9%87%8d%e7%b7%a8%e5%85%8d%e7%96%ab%e7%b4%b0%e8%83%9e%e4%bb%a5%e5%b0%8d%e6%8a%97%e7%99%8c%e7%97%87%ef%bc%9f\/"},"modified":"2026-03-23T13:31:07","modified_gmt":"2026-03-23T12:31:07","slug":"%e8%83%bd%e5%90%a6%e7%9b%b4%e6%8e%a5%e5%9c%a8%e9%ab%94%e5%85%a7%e9%87%8d%e7%b7%a8%e5%85%8d%e7%96%ab%e7%b4%b0%e8%83%9e%e4%bb%a5%e5%b0%8d%e6%8a%97%e7%99%8c%e7%97%87%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/theengineeringreview.com\/zh-tw\/2026\/03\/23\/%e8%83%bd%e5%90%a6%e7%9b%b4%e6%8e%a5%e5%9c%a8%e9%ab%94%e5%85%a7%e9%87%8d%e7%b7%a8%e5%85%8d%e7%96%ab%e7%b4%b0%e8%83%9e%e4%bb%a5%e5%b0%8d%e6%8a%97%e7%99%8c%e7%97%87%ef%bc%9f\/","title":{"rendered":"\u80fd\u5426\u76f4\u63a5\u5728\u9ad4\u5167\u91cd\u7de8\u514d\u75ab\u7d30\u80de\u4ee5\u5c0d\u6297\u764c\u75c7\uff1f"},"content":{"rendered":"

\"\u80fd\u5426\u76f4\u63a5\u5728\u9ad4\u5167\u91cd\u7de8\u514d\u75ab\u7d30\u80de\u4ee5\u5c0d\u6297\u764c\u75c7\uff1f\"<\/p>\n

\u80fd\u5426\u76f4\u63a5\u5728\u9ad4\u5167\u91cd\u7de8\u514d\u75ab\u7d30\u80de\u4ee5\u5c0d\u6297\u764c\u75c7\uff1f<\/h1>\n

\u7814\u7a76\u4eba\u54e1\u958b\u767c\u51fa\u4e00\u7a2e\u5275\u65b0\u65b9\u6cd5\uff0c\u80fd\u5920\u5728\u9ad4\u5167\u76f4\u63a5\u5c0d\u514d\u75ab\u7d30\u80de\uff08\u7a31\u70baT\u6dcb\u5df4\u7d30\u80de\uff09\u9032\u884c\u57fa\u56e0\u4fee\u98fe\u3002\u9019\u4e00\u7a81\u7834\u53ef\u80fd\u4f7f\u764c\u75c7\u548c\u67d0\u4e9b\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u7684\u6cbb\u7642\u8b8a\u5f97\u66f4\u6613\u7372\u53d6\u3001\u66f4\u6709\u6548\u4e14\u6210\u672c\u66f4\u4f4e\u3002<\/p>\n

\u76ee\u524d\uff0c\u5229\u7528\u4fee\u98fe\u5f8c\u7684T\u6dcb\u5df4\u7d30\u80de\u9032\u884c\u6cbb\u7642\uff08\u5982CAR-T\u7d30\u80de\u7642\u6cd5\uff09\u5df2\u88ab\u7528\u65bc\u6cbb\u7642\u67d0\u4e9b\u8840\u6db2\u764c\u75c7\u3002\u7136\u800c\uff0c\u9019\u4e9b\u7642\u6cd5\u7684\u88fd\u5099\u904e\u7a0b\u8907\u96dc\u3001\u8017\u6642\u4e14\u6602\u8cb4\uff0c\u9700\u8981\u5f9e\u60a3\u8005\u9ad4\u5167\u63d0\u53d6\u7d30\u80de\uff0c\u5728\u5be6\u9a57\u5ba4\u4e2d\u9032\u884c\u4fee\u98fe\uff0c\u518d\u91cd\u65b0\u6ce8\u5165\u60a3\u8005\u9ad4\u5167\u3002\u9019\u7a2e\u65b0\u65b9\u6cd5\u901a\u904e\u76f4\u63a5\u5728\u9ad4\u5167\u9032\u884c\u4fee\u98fe\uff0c\u7e5e\u904e\u4e86\u9019\u4e9b\u969c\u7919\u3002<\/p>\n

\u79d1\u5b78\u5bb6\u5011\u958b\u767c\u4e86\u4e00\u7a2e\u5229\u7528\u5169\u7a2e\u985e\u578b\u8f09\u9ad4\u7684\u7cfb\u7d71\u3002\u7b2c\u4e00\u7a2e\u7a31\u70ba\u5305\u88f9\u8f09\u9ad4\uff0c\u651c\u5e36\u91dd\u5c0dT\u6dcb\u5df4\u7d30\u80de\u7684\u57fa\u56e0\u4fee\u98fe\u5de5\u5177\u3002\u7b2c\u4e8c\u7a2e\u662f\u6539\u9020\u5f8c\u7684\u817a\u75c5\u6bd2\uff0c\u8ca0\u8cac\u5c07\u6cbb\u7642\u6027\u57fa\u56e0\u63d2\u5165\u3002\u9019\u5169\u7a2e\u8f09\u9ad4\u5354\u540c\u4f5c\u7528\uff0c\u80fd\u5920\u7cbe\u78ba\u5730\u5c07\u65b0\u57fa\u56e0\u6574\u5408\u5230T\u6dcb\u5df4\u7d30\u80de\u7684DNA\u4e2d\uff0c\u800c\u4e0d\u5f71\u97ff\u5176\u4ed6\u7d30\u80de\u3002<\/p>\n

\u70ba\u63d0\u9ad8\u6548\u7387\u548c\u5b89\u5168\u6027\uff0c\u7814\u7a76\u4eba\u54e1\u5c0d\u9019\u4e9b\u8f09\u9ad4\u9032\u884c\u4e86\u512a\u5316\u3002\u4ed6\u5011\u958b\u767c\u51fa\u4e00\u7a2e\u80fd\u62b5\u6297\u5929\u7136\u6297\u9ad4\u963b\u65b7\u4f5c\u7528\u7684\u7248\u672c\uff0c\u4e26\u6dfb\u52a0\u4e86\u4e00\u7a2e\u80fd\u6fc0\u6d3bT\u6dcb\u5df4\u7d30\u80de\u7684\u5206\u5b50\uff0c\u5f9e\u800c\u589e\u52a0\u53ef\u4fee\u98fe\u7d30\u80de\u7684\u6578\u91cf\u3002\u901a\u904e\u9019\u4e9b\u6539\u9032\uff0c\u5728\u4eba\u6e90\u5316\u5c0f\u9f20\u7684\u813e\u81df\u4e2d\uff0c\u9ad8\u905420%\u7684T\u6dcb\u5df4\u7d30\u80de\u88ab\u6210\u529f\u4fee\u98fe\u3002<\/p>\n

\u9019\u4e9b\u91cd\u7de8\u7a0b\u7684T\u6dcb\u5df4\u7d30\u80de\u5728\u591a\u7a2e\u75be\u75c5\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u6d88\u9664\u764c\u7d30\u80de\u7684\u80fd\u529b\u3002\u5b83\u5011\u80fd\u5920\u63a7\u5236\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u7624\uff0c\u751a\u81f3\u662f\u8089\u7624\uff08\u4e00\u7a2e\u5be6\u9ad4\u816b\u7624\uff09\u7684\u9032\u5c55\u3002\u8207\u73fe\u6709\u65b9\u6cd5\u4e0d\u540c\uff0c\u9019\u7a2e\u6280\u8853\u7522\u751f\u7684\u7d30\u80de\u5177\u6709\u5747\u52fb\u7684\u6d3b\u6027\u548c\u6301\u4e45\u6027\uff0c\u5f9e\u800c\u63d0\u9ad8\u4e86\u5c0d\u816b\u7624\u7684\u6cbb\u7642\u6548\u679c\u3002<\/p>\n

\u9019\u7a2e\u65b9\u6cd5\u70ba\u66f4\u7c21\u55ae\u3001\u66f4\u5feb\u901f\u7684\u6cbb\u7642\u958b\u95e2\u4e86\u9053\u8def\u3002\u5b83\u907f\u514d\u4e86\u63d0\u53d6\u548c\u5be6\u9a57\u5ba4\u57f9\u990a\u7684\u6b65\u9a5f\uff0c\u964d\u4f4e\u4e86\u6210\u672c\u548c\u6642\u9593\u3002\u6b64\u5916\uff0c\u5b83\u9084\u53ef\u4ee5\u61c9\u7528\u65bc\u5176\u4ed6T\u6dcb\u5df4\u7d30\u80de\u767c\u63ee\u95dc\u9375\u4f5c\u7528\u7684\u75be\u75c5\uff0c\u5982\u611f\u67d3\u6216\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u3002<\/p>\n

\u96d6\u7136\u5728\u5c0f\u9f20\u8eab\u4e0a\u7372\u5f97\u7684\u7d50\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u4f46\u4ecd\u9700\u9032\u4e00\u6b65\u7684\u4eba\u9ad4\u7814\u7a76\u4f86\u78ba\u8a8d\u5176\u6548\u679c\u548c\u5b89\u5168\u6027\u3002\u5982\u679c\u9019\u4e9b\u8a66\u9a57\u7372\u5f97\u6210\u529f\uff0c\u9019\u9805\u6280\u8853\u53ef\u80fd\u6703\u5fb9\u5e95\u6539\u8b8a\u8a31\u591a\u60a3\u8005\u7372\u53d6\u7d30\u80de\u6cbb\u7642\u7684\u65b9\u5f0f\u3002<\/p>\n

\n

R\u00e9f\u00e9rences des contenus<\/h2>\n

R\u00e9f\u00e9rence officielle<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41586-026-10235-x<\/a><\/p>\n

Titre\u00a0:<\/strong> In vivo site-specific engineering to reprogram T cells<\/p>\n

Revue : <\/strong> Nature<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> William A. Nyberg; Pierre-Louis Bernard; Wayne Ngo; Charlotte H. Wang; Jonathan Ark; Allison Rothrock; Gina M. Borgo; Gabriella R. Kimmerly; Jae Hyung Jung; Vincent Allain; Jennifer R. Hamilton; Alisha Baldwin; Robert Stickels; Sarah Wyman; Safwaan H. Khan; Shanshan Lang; Donna Marsh; Niran Almudhfar; Catherine Novick; Yasaman Mortazavi; Shimin Zhang; Mahmoud M. AbdElwakil; Luis R. Sandoval; Sidney Hwang; Simon N. Chu; Hyuncheol Jung; Chang Liu; Devesh Sharma; Travis McCreary; Zhongmei Li; Ansuman T. Satpathy; Julia Carnevale; Rachel L. Rutishauser; M. Kyle Cromer; Kole T. Roybal; Stacie E. Dodgson; Jennifer A. Doudna; Aravind Asokan; Justin Eyquem<\/p>\n","protected":false},"excerpt":{"rendered":"

\u80fd\u5426\u76f4\u63a5\u5728\u9ad4\u5167\u91cd\u7de8\u514d\u75ab\u7d30\u80de\u4ee5\u5c0d\u6297\u764c\u75c7\uff1f \u7814\u7a76\u4eba\u54e1\u958b\u767c\u51fa\u4e00\u7a2e\u5275\u65b0\u65b9\u6cd5\uff0c\u80fd\u5920\u5728\u9ad4\u5167\u76f4\u63a5\u5c0d\u514d\u75ab\u7d30\u80de\uff08\u7a31\u70baT\u6dcb\u5df4\u7d30\u80de\uff09… \u95b1\u8b80\u5168\u6587 \u80fd\u5426\u76f4\u63a5\u5728\u9ad4\u5167\u91cd\u7de8\u514d\u75ab\u7d30\u80de\u4ee5\u5c0d\u6297\u764c\u75c7\uff1f<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,3,5],"tags":[],"class_list":["post-21","post","type-post","status-publish","format-standard","hentry","category-7","category-3","category-5","entry"],"_links":{"self":[{"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/posts\/21","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/comments?post=21"}],"version-history":[{"count":1,"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/posts\/21\/revisions"}],"predecessor-version":[{"id":22,"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/posts\/21\/revisions\/22"}],"wp:attachment":[{"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/media?parent=21"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/categories?post=21"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/theengineeringreview.com\/zh-tw\/wp-json\/wp\/v2\/tags?post=21"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}